Programma

Riunione Scientifica della Scuola Dianzani

Patologia molecolare in medicina sperimentale e traslazionale

Torino – Aula Darwin, Molecular Biotechnology Center

Via Nizza 52

16-17 Novembre 2019

Con il patrocinio dei Dottorati di Ricerca in:

Medicina Molecolare (Dip. Biotecnologie Molecolari e Scienze per la Salute)

Medicina e Terapia Sperimentale (Dip. Scienze Cliniche e Biologiche)

Venerdì 16 Novembre 2018

14.00-14.15 Benvenuto ed introduzione alla Riunione Scientifica

14.15-16.15 1^ Sessione - Molecular mechanisms in the pathogenesis of chronic diseases - 1

Moderatori Alfonso Pompella, Maria Adelaide Pronzato

Toxicological impact of high fructose intake on gut microbiota and liver/intestine integrity: any differences between solid and liquid formulations?

Cento AS, Chiazza F, Ferrocino I, Bitonto V, Nigro D, Querio G, Rantsiou K, Cutrin JC, Liberto E, Masini E, Cordero C, Cocolin L, Collino M, Mastrocola R, Aragno M

Inhibition of LPS-induced intestinal barrier dysfunction by pterostilbenes and pinostilbenes: insight into the mechanism of action

Serreli G, Morales JC, Peňalver P, Melis MP, Casula E, Deiana M

Investigating neurodegenerative diseases with the metabolomics approach

Murgia F, Lorefice L, Orofino G, Solla P, Borghero G, Marrosu F, Defazio G, Cocco E, Atzori L

Mechanisms of Tau protein aggregation

Guglielmotto M, Manassero G, Monteleone D, Vasciaveo V, Arancio O, Tabaton M, Tamagno E

Investigating the molecular mechanism of the cGMP-induced amyloid-beta production

Caudano F, Passalacqua M, Pronzato MA, Fedele E, Ricciarelli R

Persistence of lung inflammation in mice following smoking cessation. Beneficial effects of formyl-peptide receptors blockade

De Cunto G, Bartalesi B, Cavarra E, Balzano E, Lungarella G, Lucattelli M

Use of HLA- DR3, DQ2 transgenic mice to identify immunodominant peptides of pancreatic autoantigens

Manchinu F, Simbula M, Schirru E, Caria C, Marongiu MF, Meloni A, Rossino R, Piludu M, Cucca F, Congia M, Muntoni S

16.15-16.30 Coffee break

16.30-17.15 2^ Sessione - Molecular mechanisms in the pathogenesis of chronic diseases - 2

Moderatori Emanuele Albano, Giuseppe Lungarella

Oxysterols and HNE contribute to plaque instability through PCSK6 up-regulation

Gargiulo S, Testa G, Gamba P, Poli G, Leonarduzzi G

Therapeutic potential of S-nitrosothiols in the prevention of atherosclerosis: modulation of monocytes and smooth muscle cells metaplasia into foam cells

Bonetti J, Corti A, Fries I, Pompella A, Gaucher C

The ribosomal phenotype of lymphoblastoid cell lines from Diamond Blackfan anemia patients can be rescued by gene complementation: a functional assay for the classification of RP variants of unknown significance

Aspesi A, Betti M, Sculco M, Actis C, Olgasi C, Wlodarski MW, Vlachos A, Lipton JM, Ramenghi U, Santoro C, Follenzi A, Ellis SR, Dianzani I

17.15-18.00 Lettura Magistrale

Ruolo della regolazione genica nelle alterazioni delle vie di trasmissione del segnale nel carcinoma epatocellulare - Rosa M. Pascale

18.00-19.00 Riunione della Scuola

20.00 Cena presso Ristorante “Catullo” – Corso Moncalieri 176

Sabato 17 Novembre 2018

8.30-10.30 3^ Sessione - Molecular mechanisms in cancer - 1

Moderatori Amedeo Columbano, Rosa M. Pascale

Inhibition of both Nrf2 and YAP expression contributes to reduce chemoresistance in bladder cancer

Daga M, Ciamporcero E, Pizzimenti S, Roetto A, Dianzani C, Barrera G

Thyroid hormone interferes with hepatocellular carcinoma (HCC) development by reverting the metabolic profile of cancer cells

Cabras L, Kowalik MA, Serra M, Perra A, Sanchez-Martin C, Rasola A, Columbano A

MicroRNA-203 inhibits MAT2A and MAT2B genes and regulates the growth and aggressiveness of hepatocellular carcinoma

Peitta G, Latte G, Simile MM, Pascale RM

Oncostatin M induces increased invasiveness and angiogenesis in hepatic cancer cells through HIF1α-related release of VEGF-A

Cannito S, Foglia B, Turato C, Di Maira G, Napione, Alvaro M, Bussolino F, Pontisso P, Marra F, Parola M

Hypoxia-inducible factor 2α is critical for NASH-related experimental liver carcinogenesis

Sutti S, Foglia B, Morello E, Cannito S, Novo E, Bocca C, Bruzzì S, Ramavath NN, Rosso C, Younes R, Bugianesi E, Parola M, Albano E

Role of alterations of the lysosomal compartment in determining susceptibility or resistance to tamoxifen in MCF7 cells

Actis C, Autelli R

Evaluation of syndecan-1 and B-Fibronectin as potential therapeutic targets in ovarian cancer

Orecchia P, Balza E, Pietra G, Ferrero S, Mingari MC, Carnemolla B

Targeting CD44/xCT enhances the sensitivity of neuroblastoma stem cells to Etoposide

Speciale A, Marengo B, Traverso N, Monteleone L, Cantoni C, Ravera S, Garbarino O, Marinari UM, Pronzato MA, Domenicotti C

10.30-10.45 Coffee break

10.45-12.30 4^ Sessione - Molecular mechanisms in cancer - 2

Moderatori Federica Cavallo, Umberto Dianzani

Effects of mitochondrial targeting with SS-31 in cancer-induced muscle wasting

Ballarò R, Beltrà M, Costelli P, Szeto H and Penna F

Anti-tumor effect of icos-fc loaded in biocompatible and biodegradable nanoparticles

Boggio E, Clemente N, Gigliotti CL, Argenziano M, Chiocchetti A, Dianzani C, Cavalli R, Dianzani U

TLR7 agonist delays resistance to BRAF inhibitor in a murine transplantable melanoma mouse model

Bellman L, Cappellano G, Schachtl-Rieß J, Porkopi A, Seretis A, Komenda K, Tripp C, Brinckerhoff CE, Dianzani U, Stoitzner P

Identification of chemotherapy-induced self antigens suitable for DNA vaccination in pancreatic cancer

Bulfamante S, Mandili G, Curcio C, Follia L, Ferrero G, Mazza E, Principe M, Cordero F, Evangelista A, Giordano D, Viet D, Spadi R, Satolli MA, Cappello P, Novelli F

DNA-vaccination strategy combined with IL17 depletion in pancreatic ductal adenocarcinoma treatment

Mucciolo G, Curcio C, Roux C, Curto R, Barutello G, Novelli F, Cappello P

Bovine herpesvirus 4-based vector delivering DNA coding for the cystine/glutamate antiporter xCT eficiently protects mice from mammary cancer metastases by targeting cancer stem cells

Conti L, Donofrio G, Tebaldi G, Lanzardo S, Ruiu R, Bolli E, Ballatore A, Rolih V, Macchi F, Cavallo F

Anti-CSPG4 DNA vaccination as a promising immunotherapy for canine and human oncology patients

Riccardo F, Barutello G, Tarone L, Arigoni M, Rolih V, Bolli E, Occhipinti S, Ferrone S, Quaglino E, Buracco P, Cavallo F

12.45-13.00 Conclusioni

13.00 Lunch